The function of the thyroid in the kinetic chain is best evidenced, however, by its role in the production of fever. Fever results from the administration of thyroid extract alone in large doses. In the hyperactivity of the thyroid in exophthalmic goiter one sees a marked tendency to fever, in severe cases there is daily fever. In fact, in Graves' disease we find displayed to an extraordinary degree an exaggeration of the whole action of the kinetic mechanism.英文原著 · 《The Origin and Nature of Emotions》
Excessive thyroid secretion, as in thyrotoxicosis from functioning adenomata, and excessive thyroid feeding, cause all the phenomena of Graves' disease except the exophthalmos and the emotional facies (Figs. 15 and 23). The ligation of arteries, the division of its nerve supply, or the excision of part of the gland, may reverse the foregoing picture and restore the normal condition. The patient notes the effect on the second day and often within a week is relatively quiescent. On the contrary, if there is thyroid deficiency there results the opposite state, a reptilian sluggishness.英文原著 · 《The Origin and Nature of Emotions》
On the other hand, when there is too little or no thyroid gland, the individual becomes dull, stupid, and emotionless, though he may be irritable; while if a sufficient amount of thyroid extract be given to such a patient he may be brought back to his normal condition.英文原著 · 《The Origin and Nature of Emotions》
Graves' disease may be increased by giving thyroid extract and by fear. It may be diminished by removing a part of the gland, or by interrupting the blood and nerve supply, or by complete rest. In addition, at some stage of Graves' disease there is an increase in the size and in the number of the secreting cells. These facts regarding the normal and the pathologic supply of thyroid secretion point to this gland as one of the sources of the energizing substance or substances, by means of which the motor phenomena of animals are executed and their emotions expressed.英文原著 · 《The Origin and Nature of Emotions》
Exophthalmic goiter may result from long emotional or mental stress in those cases in which the thyroid takes the brunt of the strain upon the mechanism. As adrenalin increases blood-pressure, so thyroid secretion increases brain activity, and increased brain activity in turn causes an increased activation of the motor mechanism as a whole.英文原著 · 《The Origin and Nature of Emotions》
The principal organs which comprise the kinetic system are the brain, the thyroid, the adrenals, the liver, and the muscles. The brain is the great central battery which drives the body; the thyroid governs the conditions favoring tissue oxidation; the adrenals govern immediate oxidation processes; the liver fabricates and stores glycogen; and the muscles are the great converters of latent energy into heat and motion.英文原著 · 《The Origin and Nature of Emotions》